They really should be cast as siblings

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1.
Courteney Cox
Actress, Friends
Courteney Cox was born on June 15th, 1964 in Birmingham, Alabama, into an affluent Southern family. She is the daughter of Courteney (Bass) and Richard Lewis Cox (1930-2001), a businessman. She was the baby of the family with two older sisters (Virginia and Dottie) and an older brother, Richard, Jr...
 
2.
Jennifer Connelly
Jennifer Connelly was born in the Catskill Mountains, New York, to Ilene (Schuman), a dealer of antiques, and Gerard Connelly, a clothing manufacturer. Her father had Irish and Norwegian ancestry, and her mother was from a Jewish immigrant family. Jennifer grew up in Brooklyn Heights, just across the Brooklyn Bridge from Manhattan...
 
3.
Josh Duhamel
Joshua David Duhamel was born in Minot, North Dakota. His mother, Bonny L., is a retired high school teacher, and the Executive Director of Minot's Downtown Business & Profession Association, and his father, Larry Duhamel, is an advertisement salesman. Josh has three younger sisters: Ashlee, McKenzee and Kassidy...
 
4.
Timothy Olyphant
Actor, Justified
From Timothy Olyphant's first screen appearances, such as his two-minute bit in The First Wives Club, to "Nicko", whose presence at times dwarfed the island in A Perfect Getaway, he has been a force to be reckoned with. Born in Hawaii, Timothy David Olyphant was raised in Modesto, California. He is the son of Katherine Lyon (Gideon) and John Vernon Bevan Olyphant...
 
5.
Drea de Matteo
Actress, The Sopranos
Andrea Donna de Matteo, called Drea (pronounced "dray"), was born on January 19, 1972 in Queens, New York, into an affluent family, the youngest of three children and the only girl. She is the daughter of Donna, a playwright and playwriting teacher at HB Studio in New York, and Albert A. De Matteo, a furniture manufacturer...
 
6.
Portia de Rossi
Portia de Rossi was born and raised in Geelong, Australia. Originally born Amanda Rogers, at 15 she changed her name to Portia, saying that it was the most daring thing she had ever done up until that point. After graduating from high school, she attended the University of Melbourne, and studied law...
 
7.
Mark Strong
British actor Mark Strong, who played Jim Prideaux in the 2011 remake of Tinker Tailor Soldier Spy, is often cast as cold, calculating villains. But before he became a famous actor, he intended to pursue a career in law. Strong was born Marco Giuseppe Salussolia in London, England, to an Austrian mother and an Italian father...
 
8.
Andy Garcia
One of Hollywood's most private and guarded leading men, Andy Garcia has created a few iconic characters while at the same time staying true to his acting roots and personal projects. Garcia was born Andrés Arturo García Menéndez on April 12, 1956, in Havana, Cuba, to Amelie Menéndez, a teacher of English...
 
9.
Kate Beckinsale
Actress, Underworld
Kate Beckinsale was born on 26 July 1973 in England, and has resided in London for most of her life. Her mother is Judy Loe, who has appeared in a number of British dramas and sitcoms and continues to work as an actress, predominantly in British television productions. Her father was Richard Beckinsale...
 
10.
Evangeline Lilly
Actress, Lost
Evangeline Lilly, born in Fort Saskatchewan, Alberta in 1979, was discovered on the streets of Kelowna, British Columbia by the famous Ford modeling agency. Although she initially decided to pass on a modeling career, she went ahead and signed with Ford anyway, to help pay for her University of British Columbia tuition and expenses.
 
11.
Jared Leto
In the vein of musicians-turned-actors, Jared Leto is a very familiar face in recent film history. Although he has always been the lead vocals, rhythm guitar, and songwriter for American band Thirty Seconds to Mars, Leto will always be remembered as an accomplished actor for the numerous, challenging projects he has taken in his life. He is known to be selective about his film roles...
 
12.
Jake Gyllenhaal
Jacob Benjamin Gyllenhaal was born in Los Angeles, California, to producer/screenwriter Naomi Foner (née Achs) and director Stephen Gyllenhaal. He is the brother of actress Maggie Gyllenhaal, who played his sister in Donnie Darko. His godmother is actress Jamie Lee Curtis. His mother is from a Jewish family, and his father's ancestry includes Swedish, English and Swiss-German...
 
13.
Robin Wright
Actress, Forrest Gump
Robin Gayle Wright was born in Dallas, Texas, to Gayle (Gaston), a national director at Mary Kay, and Freddie Wright, a pharmaceutical executive. She grew up in San Diego, California. She started her professional career as a model in 1980 at age 14, and worked both in Paris and Japan. After finishing high school she decided to become an actress...
 
14.
Elizabeth Banks
Elizabeth Banks was born Elizabeth Mitchell in Pittsfield, a small city in the Berkshires in western Massachusetts near the New York border, on February 10, 1974. She is the daughter of Ann (Wallace), who worked in a bank, and Mark P. Mitchell, a factory worker. Elizabeth describes herself as having been seen as a "goody two-shoes" in her youth who was nominated for the local Harvest Queen...
 
15.
Amanda Peet
Actress, 2012
Amanda Peet was born and raised in New York City. She is the daughter of Penny (Levy), a social worker, and Charles Peet, a lawyer, and has an older sister. Her father was of mostly English and German ancestry, and her mother was from a Jewish family (from Germany, Russia, and Hungary). Peet's great-grandfathers were politician Samuel Levy and showbiz impresario S.L. Rothafel...
 
16.
Bradley Cooper
Bradley Charles Cooper was born on January 5, 1975 in Philadelphia, Pennsylvania. His mother, Gloria (Campano), is of Italian descent, and worked for a local NBC station. His father, Charles John Cooper, who was of Irish descent, was a stockbroker. Immediately after Bradley graduated from the Honors English program at Georgetown University in 1997...
 
17.
Ralph Fiennes
Actor Ralph Nathaniel Twisleton-Wykeham-Fiennes was born on December 22, 1962 in Suffolk, England, to Jennifer Anne Mary Alleyne (Lash), a novelist, and Mark Fiennes, a photographer. He is the eldest of six children. Four of his siblings are also in the arts: Martha Fiennes, a director; Magnus Fiennes...
 
18.
Josh Lucas
Josh Lucas was born in Little Rock, Arkansas, to Michele (LeFevre), a nurse midwife, and Don Maurer, an ER doctor. Lucas' film career began by accident in 1979 when a small Canadian film production shot on the tiny coastal South Carolina Island, Sullivan's Island, where Lucas and his family lived. Unbeknownst to the filmmakers...
 
19.
Matthew McConaughey
American actor and producer Matthew David McConaughey was born in Uvalde, Texas. His mother, Mary Kathleen (McCabe), is a substitute school teacher originally from New Jersey. His father, James Donald McConaughey, was a Mississippi-born gas station owner who ran an oil pipe supply business. He is of Irish...
 
20.
Olivia Wilde
Actress, Rush
Actress and activist Olivia Wilde is a modern day renaissance woman, starring in many of Hollywood's acclaimed productions, while simultaneously giving back to the community. Wilde was born on March 10, 1984 in New York City. Her parents are Leslie Cockburn (née Leslie Corkill Redlich) and Andrew Cockburn...
 
21.
Claire Forlani
Claire Forlani was born in the United Kingdom and grew up in London. Educated at Arts Educational School, she moved to the United States with her parents Pier Luigi and Barbara Forlani when she was 19 and began starring in films. Claire has had leading roles in such films as Meet Joe Black, Basquiat...
 
22.
Ryan Phillippe
Ryan Phillippe was born on September 10, 1974 in New Castle, Delaware, to Susan (Thomas), a nurse, and Richard Phillippe, a chemical technician. He has three sisters, Kirsten, Lindsay, and Katelyn, and attended New Castle Baptist Academy. Ryan's acting career began with the soap opera One Life to Live...
 
23.
Justin Timberlake
Soundtrack, Love Actually
Justin Randall Timberlake was born on January 31, 1981, in Memphis, Tennessee, to Lynn (Bomar) and Randall Timberlake, whose own father was a Baptist minister. At the age of 11, he appeared on the show Star Search, and even though he didn't win, it didn't dampen his ambitions. He also appeared on The All New Mickey Mouse Club...
 
24.
Zoe Saldana
Actress, Avatar
Zoe Saldana was born on June 19, 1978 in Passaic, New Jersey, to Asalia Nazario and Aridio Saldaña. Her father was Dominican and her mother is Puerto Rican. She was raised in Queens, New York. When she was 10 years old, she and her family moved to the Dominican Republic, where they would live for the next seven years...
 
25.
Thandie Newton
Thandie Newton was born in London. She is the daughter of a Zimbabwean mother, Nyasha, a health-care worker from the Shona tribe, and Nick Newton, a British father who worked as a lab technician. She lived in Zambia until political unrest caused her family to move back to the UK. She then lived in Cornwall in the southwest of Britain until the age of 11...
 
26.
Kurt Russell
Kurt Russell was born Kurt Vogel Russell in Springfield, Massachusetts, to Louise Julia (Crone), a dancer, and actor Bing Russell (Neil Oliver Russell). He is of English, German, Scottish and Irish descent. His first roles were as a child on television series, including a lead role on the Western series The Travels of Jaimie McPheeters...
 
27.
Jeff Bridges
Jeffrey Leon Bridges was born on December 4, 1949 in Los Angeles, California, the son of well-known film and TV star Lloyd Bridges and his long-time wife Dorothy Dean Bridges (née Simpson). He grew up amid the happening Hollywood scene with big brother Beau Bridges. Both boys popped up, without billing...
 
28.
Amy Adams
Actress, Arrival
Amy Lou Adams was born in Vicenza, Veneto, Italy, to American parents, Kathryn (Hicken) and Richard Kent Adams, a U.S. serviceman who was stationed at Caserma Ederle in Italy at the time. She was raised in a Mormon family of seven children in Castle Rock, Colorado, and has English, as well as smaller amounts of Danish, Swiss-German, and Norwegian, ancestry...
 
29.
Isla Fisher
Actress, Home and Away
Isla Lang Fisher was born on February 3, 1976 in Muscat, Oman, to Scottish parents Elspeth Reid and Brian Fisher, who worked as a banker for the U.N. She spent her early childhood in Scotland before moving to Australia with her family in the early 1980s. From a young age, Isla showed an interest in both acting and writing...
 
30.
Nathan Fillion
Actor, Castle
Nathan Fillion was born on 27 March 1971 in Edmonton, Alberta, Canada. He is the son of Cookie (Early) and Bob Fillion, both retired English teachers, and has an older brother, Jeff. In Canada, he attended Holy Trinity Catholic High School, Concordia University College of Alberta and University of Alberta...
 
31.
Jason Bateman
Jason Bateman is an American film and television actor best known for his role as Michael Bluth on the television sitcom Arrested Development, as well as his role on Valerie. He was born in Rye, New York, USA. His father, Kent Bateman, from a Utah-based family, is a film and television director...
 
33.
Amanda Seyfried
Actress, Mamma Mia!
Amanda Seyfried was born and raised in Allentown, Pennsylvania, to Ann (Sander), an occupational therapist, and Jack Seyfried, a pharmacist. She is of German, and some English and Scottish, ancestry. She began modeling when she was eleven, and acted in high school productions as well as taking singing lessons...
 
35.
Hugh Dancy
Actor, Hannibal
Talented British actor Hugh Dancy is one of the UK's most up-and-coming talents. Hugh Michael Horace Dancy was born in Stoke-on-Trent, Staffordshire, England, to Sarah Ann (Birley), who works in academic publishing, and Jonathan Peter Dancy, a philosophy professor and writer. He has a brother, Jack (b. 1977), and a sister, Kate (b. 1980). He was raised in Newcastle-under-Lyme...
 
37.
Leelee Sobieski
Actress, Joy Ride
Liliane Rudabet Gloria Elsveta Sobieski was born June 10, 1983 in New York City, New York. She is the daughter of Elizabeth Sobieski (née Salomon), a writer, and Jean Sobieski, a painter who has also acted. She has a younger brother, Robert. Her father, born in France, is of Polish and Swiss descent, while her mother is of three quarters Ashkenazi Jewish and one quarter Dutch, ancestry...
 
38.
Helen Hunt
Actress, Mad About You
Helen Hunt began studying acting at the age of eight with her father, respected director and acting coach Gordon Hunt. A year later she made her professional debut and afterwards worked steadily in films, theatre and television.
 
39.
Jeffrey Dean Morgan
Actor, Watchmen
Jeffrey Dean Morgan endeared himself to audiences with his recurring role on ABC's smash hit series, Grey's Anatomy. His dramatic arc as heart patient "Denny Duquette", who wins the heart of intern "Izzie Stevens" (Katherine Heigl) in a star-crossed romance, made him a universal fan favorite. He also had recurring roles on The CW and Warner Bros...
 
40.
Javier Bardem
Javier Bardem is the youngest member of a family of actors that has been making films since the early days of Spanish cinema. He was born in Las Palmas de Gran Canaria, Spain, to actress Pilar Bardem (María del Pilar Bardem Muñoz) and businessman José Carlos Encinas Doussinague. His maternal grandparents were actors Rafael Bardem and Matilde Muñoz Sampedro...
 
41.
Emily Browning
Actress, Sucker Punch
Emily Browning is an Australian actress and singer. She made her film debut in the Australian television film The Echo of Thunder (1998). Browning is also known for her roles in the horror film The Uninvited (2009), the action film Sucker Punch (2011), the independent drama Sleeping Beauty (2011), The Host (2013), Pompeii (2014) and Legend (2015).
 
42.
Alexis Bledel
Actress, Gilmore Girls
Kimberly Alexis Bledel was born in Houston, Texas, to Nanette (Dozier) and Martin Bledel. Her parents are both Spanish-speakers (her mother was born in Arizona and raised in Mexico, and her father was born in Argentina), and Alexis's ancestry includes Danish, Welsh, English, Scottish, Irish, and French...