Was supposed to film in New Orleans, Louisiana, however, switched locations after Hurricane Katrina devastated the city.
The ventilator was a real working ventilator. An artificial lung was placed off camera to make it work.
The part of Nate Tanner was originally supposed to be James Dalton, Patrick Swayze's character from the first Road House (1989), but Swayze backed out due to creative differences, and the character was changed.